ADWIA

Company Information

History : ADWIA Pharmaceuticals, one of the leading Egyptian companies. ADWIA pharmaceuticals was founded in 1984 with the mission to bring the latest technologies and the highest available know-how in the international scene to the local market.

  

  

Logo

  • Type Of Company: International - pharmaceutical

  • Size Of Company:

    Medium

    400-500 Employees

  • Range of expected salary for med. Rep.: After Interview

  • Car policy: Yes

  • Incentive scheme: yes

  • Factory: yes

  • Company rank (IMS) 2018: 23

  • company link: http://www.adwia.com

Products

Trade NameGeneric NameCompanyPharmacology PriceDescription
ABSTAIN SR 150 MG 20 TAB.BUPROPIONADWIApsychiatric.Antidepressants20About Bupropion*Norepinephrine and dopamine reuptake inhibitor,nicotinic antagonist, aminoketone derivative, Atypical antidepressant, Smoking Cessation Aid.*Mechanism of Action of Bupropion*Bupropion blocks the re-uptake of neurotransmitter Dopamine and Noradrenaline from the synapse in to the presynaptic nerve terminal in the CNS. It has only a less activity in blocking the reuptake of Serotonin. Bupropion potentiates the noradrenergic and Dopaminergic activity and produces antidepressant activity. *Smoking cessation action: Bupropion is a competitive antagonist of nicotine. *Indications for Bupropion*1. Depression *2. Smoking cessation treatment
ADWIFLAM 25MG 20F.C.TABDICLOFENAC POTASSIUMADWIANSAID.Acetic acid derivatives7About Diclofenac PotassiumSNSAID, anti-inflammatory ,antipyretic and analgesic.SSMechanism of Action of Diclofenac PotassiumSDiclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.SSIndications for Diclofenac PotassiumS1.Rheumatoid arthritis S2.Ankylosing spondylitis S3.Acute gout S4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints S5.Osteoarthritis S6.For the relief of pain and inflammation in dental minor surgery and orthopedic S7.Dysmenorrhoea
ADWIFLAM 25mg children 5 supp.DICLOFENAC POTASSIUMADWIANSAID.Acetic acid derivatives8About Diclofenac Potassium*NSAID, anti-inflammatory ,antipyretic and analgesic.**Mechanism of Action of Diclofenac Potassium*Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.**Indications for Diclofenac Potassium*1.Rheumatoid arthritis *2.Ankylosing spondylitis *3.Acute gout *4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints *5.Osteoarthritis *6.For the relief of pain and inflammation in dental minor surgery and orthopedic *7.Dysmenorrhoea
ADWIFLAM 50 MG 10 SACHETSDICLOFENAC POTASSIUMADWIANSAID.Acetic acid derivatives22.5About Diclofenac Potassium*NSAID, anti-inflammatory ,antipyretic and analgesic.**Mechanism of Action of Diclofenac Potassium*Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.**Indications for Diclofenac Potassium*1.Rheumatoid arthritis *2.Ankylosing spondylitis *3.Acute gout *4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints *5.Osteoarthritis *6.For the relief of pain and inflammation in dental minor surgery and orthopedic *7.Dysmenorrhoea
ADWIFLAM 50mg E.R. 30 caps.DICLOFENAC POTASSIUMADWIANSAID.Acetic acid derivatives29.25About Diclofenac Potassium*NSAID, anti-inflammatory ,antipyretic and analgesic.**Mechanism of Action of Diclofenac Potassium*Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.**Indications for Diclofenac Potassium*1.Rheumatoid arthritis *2.Ankylosing spondylitis *3.Acute gout *4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints *5.Osteoarthritis *6.For the relief of pain and inflammation in dental minor surgery and orthopedic *7.Dysmenorrhoea
ADWIFLAM 75mg 5 supp.DICLOFENAC POTASSIUMADWIANSAID.Acetic acid derivatives10.5About Diclofenac Potassium*NSAID, anti-inflammatory ,antipyretic and analgesic.**Mechanism of Action of Diclofenac Potassium*Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.**Indications for Diclofenac Potassium*1.Rheumatoid arthritis *2.Ankylosing spondylitis *3.Acute gout *4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints *5.Osteoarthritis *6.For the relief of pain and inflammation in dental minor surgery and orthopedic *7.Dysmenorrhoea
ADWIFLAM 75mg/3ml 6 AMP.DICLOFENAC POTASSIUMADWIANSAID.Acetic acid derivatives29.25About Diclofenac Potassium*NSAID, anti-inflammatory ,antipyretic and analgesic.**Mechanism of Action of Diclofenac Potassium*Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.**Indications for Diclofenac Potassium*1.Rheumatoid arthritis *2.Ankylosing spondylitis *3.Acute gout *4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints *5.Osteoarthritis *6.For the relief of pain and inflammation in dental minor surgery and orthopedic *7.Dysmenorrhoea
ADWINERVE 500 mcg 20 Caps.MECOBALAMINADWIA8About Mecobalamin*Water soluble, Form of Vitamin B12**Mechanism of Action of Mecobalamin*Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.**Indications for Mecobalamin*1.Peripheral neuropathies *2.Megaloblastic anaemia **Interactions for Mecobalamin*1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines *2.Reduced serum concentrations with oral contraceptives *3.Reduced effects in anaemia with parenteral chloramphenicol
ADWINERVE PLUS 20 Caps.VITAMIN B1--VITAMIN B6--VITAMIN B12ADWIA8.5About Vit B1**Physiological functions: Thiamine pyrophosphate is a coenzyme and the active form of vitamin B. It functions as coenzyme in decarboxylation of a-keto acid and in Hexose Monophosphate shunt. *Deficiency symptoms: In severe vitamin B1 deficiency beriberi develops. It is of two types: *a) Wet beriberi *b) Dry beriberi *Wet beriberi: In this the symptoms are related to the cardiovascular system and they are palpitations, tachycardia, dyspnoea, ECG changes, oedema, and high output cardiac failure. *Dry beriberi: The symptoms and signs are related to the Nervous system. The main features are peripheral neuritis, hyperaesthesia (localized areas) or anaesthesia, there is gradual loss in muscle strength, wrist drop, poor memory, depression, lack of initiative and anorexia.*Mechanism of Action of Vit B2*Riboflavin exerts it`s action by influencing metabolic reactions. Riboflavin functions in the forms of flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) wh
ADWIPRAZOLE 10mg 30 F.C. Tab.ARIPIPRAZOLEADWIApsychiatric.Antipsychotics90About Aripiprazole*Second-Generation Atypical Antipsychotic, dopamine-serotonin stabilizer. *Mechanism of Action of Aripiprazole*The mechanism of action of Aripiprazole in the treatment of schizophrenia and bipolar disorder is unknown. The proposed mechanism is that Aripiprazole acts by combination of partial agonist activity at Dopamine (D2) and Serotonin (5HT1A) receptor and a potent antagonist at 5HT2A receptor. *Aripiprazole also has an antagonist activity at alpha1 adrenergic receptors. *Indications for Aripiprazole*1.Schizophrenia *2.Bipolar disorder *Interactions for Aripiprazole*Carbamazepine: It cause an increase in Aripiprazole clearance and lower blood levels *Ketoconazole, Quinidine, Fluoxetine, Paroxetine: They inhibt Aripirazole elimination and cause increased blood levels.
ADWIPRAZOLE 30mg 10f.c.tab.ARIPIPRAZOLEADWIApsychiatric.Antipsychotics40About Aripiprazole*Second-Generation Atypical Antipsychotic, dopamine-serotonin stabilizer. *Mechanism of Action of Aripiprazole*The mechanism of action of Aripiprazole in the treatment of schizophrenia and bipolar disorder is unknown. The proposed mechanism is that Aripiprazole acts by combination of partial agonist activity at Dopamine (D2) and Serotonin (5HT1A) receptor and a potent antagonist at 5HT2A receptor. *Aripiprazole also has an antagonist activity at alpha1 adrenergic receptors. *Indications for Aripiprazole*1.Schizophrenia *2.Bipolar disorder *Interactions for Aripiprazole*Carbamazepine: It cause an increase in Aripiprazole clearance and lower blood levels *Ketoconazole, Quinidine, Fluoxetine, Paroxetine: They inhibt Aripirazole elimination and cause increased blood levels.
ADWIPRIL 2mg 10tab.PERINDOPRILADWIAAnti-hypertensive.ACE10About Perindopril*A long-acting Dicarboxylate-containing ACE inhibitor, Antihypertensive.*Mechanism of Action of Perindopril*It is a prodrug and converted in to active Perindoprilat- which is a long acting angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. The drug restores the reduced elastic properties of arteries and heart in hypertensive individuals. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality
ADWIPRIL 4 mg 30 tab.PERINDOPRILADWIAAnti-hypertensive.ACE45About Perindopril*A long-acting Dicarboxylate-containing ACE inhibitor, Antihypertensive.*Mechanism of Action of Perindopril*It is a prodrug and converted in to active Perindoprilat- which is a long acting angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. The drug restores the reduced elastic properties of arteries and heart in hypertensive individuals. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality
ADWISOMN 25 MG 20 CAP.DOXYLAMINE SUCCINATEADWIAAntihistamine7.3
ADWIVALSAR 160mg 30 Scored F.C. TABS.VALSARTANADWIAAnti-hypertensive.angiotensin blocker57About Valsartan*Angiotensin II receptor antagonist, Antihypertensive.*Mechanism of Action of Valsartan*It is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.*Indications for Valsartan*1. Hypertension*Interactions for Valsartan*Potassium-sparing diuretics (e.g., Spironolactone, Triamterene, Amiloride), Potassium supplements, or Salt substitutes containing potassium: Concomitant use of Valsartan with these drugs will result in hyperkalaemia and in heart failure patients it increases serum creatinine.
ADWIVALSAR-CO 160/12.5mg 10 scored F.C.tab.HYDROCHLOROTHIAZIDE--VALSARTANADWIAAnti-hypertensive. combined angiotensin blocker with diuretic23About Hydrochlorothiazide*Thiazide derivatibve, Diuretic.*Mechanism of Action of Hydrochlorothiazide*It is thiazide diuretic which exerts its action by acting at site-3(central dilating segment of early distal tubule). It binds to Na Cl- symporter and inhibits Na Cl- symport at the luminal membrane. It has additional carbonic anhydrase inhibitory actions in proximal tubules. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2 excretion and increases Mg2 excretion. It also has minor carbonic anhydrase inhibitory action. It also causes direct arteriolar vasodilatation and decreases total peripheral resistance. The antihypertensive actions of the drug may be attributable to depletion of sodium and subsequent reduction in plasma volume and a decrease in peripheral resistance. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive he
ADWIVALSAR-CO 160/25mg 10 scored F.C. Tab.HYDROCHLOROTHIAZIDE--VALSARTANADWIAAnti-hypertensive. combined angiotensin blocker with diuretic24About Hydrochlorothiazide*Thiazide derivatibve, Diuretic.*Mechanism of Action of Hydrochlorothiazide*It is thiazide diuretic which exerts its action by acting at site-3(central dilating segment of early distal tubule). It binds to Na Cl- symporter and inhibits Na Cl- symport at the luminal membrane. It has additional carbonic anhydrase inhibitory actions in proximal tubules. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2 excretion and increases Mg2 excretion. It also has minor carbonic anhydrase inhibitory action. It also causes direct arteriolar vasodilatation and decreases total peripheral resistance. The antihypertensive actions of the drug may be attributable to depletion of sodium and subsequent reduction in plasma volume and a decrease in peripheral resistance. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive he
AMADOL 100mg S.R. 10 tab.TRAMADOLADWIAAnalgesics.Narcotic Opioid9(Indications):* This medication is an opioid analgesic, prescribed for moderate to severe pain in adults.It works by changing the way the body senses pain. **(Contraindications):* acute alcoholism, head injuries, severe kidney impairment, breastfeeding, hypersensitivity**(Dosage):*The recommended dose is 50-100 mg (immediate release tablets) every 4-6 hours as needed for pain. The maximum dose is 400 mg/day.*IV/IM-Moderate to severe pain- The recommended dose is 50-100 mg 4-6 hourly.**
AMADOL 100mg/2ml 3 amp.TRAMADOLADWIAAnalgesics.Narcotic Opioid7.65(Indications):* This medication is an opioid analgesic, prescribed for moderate to severe pain in adults.It works by changing the way the body senses pain. **(Contraindications):* acute alcoholism, head injuries, severe kidney impairment, breastfeeding, hypersensitivity**(Dosage):*The recommended dose is 50-100 mg (immediate release tablets) every 4-6 hours as needed for pain. The maximum dose is 400 mg/day.*IV/IM-Moderate to severe pain- The recommended dose is 50-100 mg 4-6 hourly.**
AMADOL 50mg 20 hard gelatin Caps.TRAMADOLADWIAAnalgesics.Narcotic Opioid12.7(Indications):* This medication is an opioid analgesic, prescribed for moderate to severe pain in adults.It works by changing the way the body senses pain. **(Contraindications):* acute alcoholism, head injuries, severe kidney impairment, breastfeeding, hypersensitivity**(Dosage):*The recommended dose is 50-100 mg (immediate release tablets) every 4-6 hours as needed for pain. The maximum dose is 400 mg/day.*IV/IM-Moderate to severe pain- The recommended dose is 50-100 mg 4-6 hourly.**
AMBRODOXY 10 Caps.AMBROXOL--DOXYCYCLINEADWIA12Mechanism of Action of Doxycycline*Doxycycline is a broad spectrum antibiotic which acts against both gram positive and gram negative organisms. It exerts its bacteriostatic action by accumulating inside the bacteria through specific transporter protein and by passive diffusion & inhibits bacterial protein synthesis by attaching to 30 S subunit of bacterial ribosome (which are absent in mammals).Doxycycline interfering the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and peptide chain fails to grow. It chelates cations like Ca &Mg and inhibits functioning of various enzymes & ribosome. *Mechanism of Action of Ambroxol*Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant propertie
ANTI-COX II 15mg 10 supp.MELOXICAMADWIANSAID.Oxicam25.5About Meloxicam*NSAID, Thiazole derivative, Oxicam class, Analgesic,anti-inflammatory.**Mechanism of Action of Meloxicam*This drug reduces the prostaglandin synthesis peripherally by inhibiting COX1 & COX2 isoenzymes. This results its antinflammatory action. It is a preferential COX2 inhibitor. It also inhibits TXA2 production.**Indications for Meloxicam*1. Rheumatoid arthritis *2. Osteoarthritis *3. Ankylosing spondylitis *4. Acute gout
ANTI-COX II 15mg 20 tab.MELOXICAMADWIANSAID.Oxicam36About Meloxicam*NSAID, Thiazole derivative, Oxicam class, Analgesic,anti-inflammatory.**Mechanism of Action of Meloxicam*This drug reduces the prostaglandin synthesis peripherally by inhibiting COX1 & COX2 isoenzymes. This results its antinflammatory action. It is a preferential COX2 inhibitor. It also inhibits TXA2 production.**Indications for Meloxicam*1. Rheumatoid arthritis *2. Osteoarthritis *3. Ankylosing spondylitis *4. Acute gout
ANTI-COX II 15mg/3ml 6 AMP.MELOXICAMADWIANSAID.Oxicam31.5About Meloxicam*NSAID, Thiazole derivative, Oxicam class, Analgesic,anti-inflammatory.**Mechanism of Action of Meloxicam*This drug reduces the prostaglandin synthesis peripherally by inhibiting COX1 & COX2 isoenzymes. This results its antinflammatory action. It is a preferential COX2 inhibitor. It also inhibits TXA2 production.**Indications for Meloxicam*1. Rheumatoid arthritis *2. Osteoarthritis *3. Ankylosing spondylitis *4. Acute gout
ANTI-COX II 7.5mg 20 Caps.MELOXICAMADWIANSAID.Oxicam24About Meloxicam*NSAID, Thiazole derivative, Oxicam class, Analgesic,anti-inflammatory.**Mechanism of Action of Meloxicam*This drug reduces the prostaglandin synthesis peripherally by inhibiting COX1 & COX2 isoenzymes. This results its antinflammatory action. It is a preferential COX2 inhibitor. It also inhibits TXA2 production.**Indications for Meloxicam*1. Rheumatoid arthritis *2. Osteoarthritis *3. Ankylosing spondylitis *4. Acute gout
ANTIFLU 20 hard gelatin cap.CAFFEINE -- CHLORPHENIRAMINE -- IBUPROFEN -- PHENYLPROPANOLAMINEADWIA12.75
BLOCK ALPHA 0.4mg MR 30 hard gelatin Caps.TAMSULOSINADWIAUrination-difficulty.Alpha Blocker81About Tamsulosin*Selective Alpha1a Adrenergic Antagonist , For benign prostatic hyperplasia.*Mechanism of Action of Tamsulosin*Tamsulosin is adrenergic alpha receptor antagonist. It inhibits alpha 1A and alpha 1D subtype receptors. Tamsulosin selectively inhibits alpha 1A receptor in the prostate and leads to relaxation of smooth muscles in the bladder neck and prostate. This will improve urine flow and reduces BPH symptoms. *Adrenergic nerves releases adrenalin which produces contraction of muscles. Tamsulosin is selectively inhibit alpha 1A receptor in the prostate and bladder neck and relaxes the muscles and decrease the obstruction to the flow of urine in prostate hypertrophy. *Indications for Tamsulosin*1. Benign Prostatic hyperplasia (BPH) ***Interactions for Tamsulosin*Cimetidine: Results in significant decrease in clearance of tamsulosin AUC. *Alpha adrenergic blocking agents: Tamsulosin should not be used in combination with other alpha adrenergics.
BRONCHOFREE 20 Caps.BENZONATATE -- DIPHENHYDRAMINE -- GUAIFENESIN -- PHENYLEPHRINEADWIA14
BUTALINE 7.5mg E.R. 30 caps.TERBUTALINEADWIABronchodilator.Short-acting B2 agonist19.5About Terbutaline*A alfa2-adrenergic agonist,a fast-acting bronchodilator, Tocolytic,Anti asthma.*Mechanism of Action of Terbutaline*Terbutaline is a ?2 receptor agonist. Terbutaline directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2 -- sensitive K -- channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles. *Tocolytic action: In premature labour Terbutaline relaxes uterine smooth muscles and inhibits uterine contractions.
CRESTATIN 10 mg 10 F.C. Tabs.ROSUVASTATINADWIAAntihyperlipidemic.Statins22About Rosuvastatin*Statin, HMG-CoA Reductase Inhibitor, Antilipemic.*Mechanism of Action of Rosuvastatin*It is a hypolipidaemic statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme- 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels.
CYCLOTRONE 200mg supp.PROGESTERONEADWIA7.5"Indication *For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used for the reduction of the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy, as well as treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer.*Mechanism of action Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (lu"
DANSET 4mg/2ml 1 amp.ONDANSETRONADWIA18About Ondansetron*Selective serotonin 5-HT3 receptor antagonist, Imidazole derivative, Antiemetic.*Mechanism of Action of Ondansetron*Ondansetron is a selective 5HT3 receptor antagonist. 5HT3 receptors are present in vagal nerve terminals and chemoreceptor trigger zone of area postrema of the brain. *Cytotoxic chemotherapy is associated with release of Serotonin from Enterochromaffin cells in the small intestine. Serotonin triggers vomiting through 5HT3 vagal receptor that activates the vomiting reflex. Since Ondansetron is a 5HT3 receptor antagonist, it is indicated for the prevention of nausea and vomiting associated in chemotherapy. *Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
DANSET 4mg/2ml 3 amp.ONDANSETRONADWIA79About Ondansetron*Selective serotonin 5-HT3 receptor antagonist, Imidazole derivative, Antiemetic.*Mechanism of Action of Ondansetron*Ondansetron is a selective 5HT3 receptor antagonist. 5HT3 receptors are present in vagal nerve terminals and chemoreceptor trigger zone of area postrema of the brain. *Cytotoxic chemotherapy is associated with release of Serotonin from Enterochromaffin cells in the small intestine. Serotonin triggers vomiting through 5HT3 vagal receptor that activates the vomiting reflex. Since Ondansetron is a 5HT3 receptor antagonist, it is indicated for the prevention of nausea and vomiting associated in chemotherapy. *Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
DANSET 8mg/4ml 1 amp.ONDANSETRONADWIA27About Ondansetron*Selective serotonin 5-HT3 receptor antagonist, Imidazole derivative, Antiemetic.*Mechanism of Action of Ondansetron*Ondansetron is a selective 5HT3 receptor antagonist. 5HT3 receptors are present in vagal nerve terminals and chemoreceptor trigger zone of area postrema of the brain. *Cytotoxic chemotherapy is associated with release of Serotonin from Enterochromaffin cells in the small intestine. Serotonin triggers vomiting through 5HT3 vagal receptor that activates the vomiting reflex. Since Ondansetron is a 5HT3 receptor antagonist, it is indicated for the prevention of nausea and vomiting associated in chemotherapy. *Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
DANSET 8mg/4ml 3 amp.ONDANSETRONADWIA113.5About Ondansetron*Selective serotonin 5-HT3 receptor antagonist, Imidazole derivative, Antiemetic.*Mechanism of Action of Ondansetron*Ondansetron is a selective 5HT3 receptor antagonist. 5HT3 receptors are present in vagal nerve terminals and chemoreceptor trigger zone of area postrema of the brain. *Cytotoxic chemotherapy is associated with release of Serotonin from Enterochromaffin cells in the small intestine. Serotonin triggers vomiting through 5HT3 vagal receptor that activates the vomiting reflex. Since Ondansetron is a 5HT3 receptor antagonist, it is indicated for the prevention of nausea and vomiting associated in chemotherapy. *Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
DICLONERVE 30 Caps.DICLOFENAC SODIUM -- VITAMIN B1 -- VITAMIN B2 -- VITAMIN B12ADWIA21Mechanism of Action of Diclofenac Sodium*Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (PGs). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake. .*Pharmacokinets of Diclofenac Sodium*Absorption: Diclofenac sodium is rapidly absorbed after oral administration. It undergoes first pass metabolism and its bioavailability is 50 % only. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac sodium is metabolised in the liver. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.
DINAR 125mg/5ml 100ml susp.CEFDINIRADWIAAntibiotic.cephalosporin.third-generation49.5About Cefdinir*Semisynthetic (Third Generation ) cephalosporin antibiotic, Oral broad-spectrum antibiotic.**Mechanism of Action *Cefdinir is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & aerobic gram negative organisms by inhibiting bacterial cell wall synthesis. Cefdinir inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefdinir**Indications for Cefdinir*1.Pneumonia *2.Bronchitis *3.Pharyngitis *4.Tonsillitis *5.Skin & soft tissue infections *6.Otitismedia *7.Sinusitis
DINAR 125mg/5ml 60ml susp.CEFDINIRADWIAAntibiotic.cephalosporin.third-generation47About Cefdinir*Semisynthetic (Third Generation ) cephalosporin antibiotic, Oral broad-spectrum antibiotic.**Mechanism of Action *Cefdinir is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & aerobic gram negative organisms by inhibiting bacterial cell wall synthesis. Cefdinir inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefdinir**Indications for Cefdinir*1.Pneumonia *2.Bronchitis *3.Pharyngitis *4.Tonsillitis *5.Skin & soft tissue infections *6.Otitismedia *7.Sinusitis
DINAR 300mg 10Caps.CEFDINIRADWIAAntibiotic.cephalosporin.third-generation69About Cefdinir*Semisynthetic (Third Generation ) cephalosporin antibiotic, Oral broad-spectrum antibiotic.**Mechanism of Action *Cefdinir is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & aerobic gram negative organisms by inhibiting bacterial cell wall synthesis. Cefdinir inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefdinir**Indications for Cefdinir*1.Pneumonia *2.Bronchitis *3.Pharyngitis *4.Tonsillitis *5.Skin & soft tissue infections *6.Otitismedia *7.Sinusitis
DOXY M.R.100 mg 10 Caps.DOXYCYCLINEADWIA9About Doxycycline*Tetracycline Derivative, Antibiotic.**Mechanism of Action of Doxycycline*Doxycycline is a broad spectrum antibiotic which acts against both gram positive and gram negative organisms. It exerts its bacteriostatic action by accumulating inside the bacteria through specific transporter protein and by passive diffusion & inhibits bacterial protein synthesis by attaching to 30 S subunit of bacterial ribosome (which are absent in mammals).Doxycycline interfering the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and peptide chain fails to grow. It chelates cations like Ca &Mg and inhibits functioning of various enzymes & ribosome. **Indications for Doxycycline*1. Syphilis *2. Lympho granuloma veneram *3. Typhus fever *4. Respiratory tract infections *5. Prophylaxis of malaria *6. Urinogenital tract infections *7. Trachoma *8. Pelvic inflammatory disease*9. Acne *10. Diarrhoea *11. Gonorrhea in penicillin allergic individuals *12. Pneumonia *
EPIRAN 75mg 20 tab.RANITIDINEADWIAPeptic Ulcer.Anti-Histamine.H2 Antagonist7.2About Ranitidine*A histamine H2-receptor antagonist, Furan derivative, Anti-secretory G.I agent,Anti ulcer.*Mechanism of Action of Ranitidine*Ranitidine is a H2 (Histamine) receptor antagonist. Histamine is the most potent stimulus of acid secretion and acts as the common mediator. H2 receptor is a G-protein coupled receptor. It induces adenylate cyclase which converts ATP to cyclic AMP. This cyclic AMP acts on proton pump and exchange extracellular potassium ion for intracellular hydrogen ion across the parietal cell membrane. Ranitidine reversibly competes with Histamine for binding to H2 receptors on the parietal cells and predominantly inhibits basal acid secretion. *Anaesthetic adjuncts: It is used in patients undergoing prolonged operations, caesarian section,obese patients those are at increased risk of gastric regurgitation and aspiration pneumonia. It raises pH of gastric juice and also reduces its volume and thus chances of regurgitation.
EPIRAN 75mg 6 sachetRANITIDINEADWIAPeptic Ulcer.Anti-Histamine.H2 Antagonist4.2About Ranitidine*A histamine H2-receptor antagonist, Furan derivative, Anti-secretory G.I agent,Anti ulcer.*Mechanism of Action of Ranitidine*Ranitidine is a H2 (Histamine) receptor antagonist. Histamine is the most potent stimulus of acid secretion and acts as the common mediator. H2 receptor is a G-protein coupled receptor. It induces adenylate cyclase which converts ATP to cyclic AMP. This cyclic AMP acts on proton pump and exchange extracellular potassium ion for intracellular hydrogen ion across the parietal cell membrane. Ranitidine reversibly competes with Histamine for binding to H2 receptors on the parietal cells and predominantly inhibits basal acid secretion. *Anaesthetic adjuncts: It is used in patients undergoing prolonged operations, caesarian section,obese patients those are at increased risk of gastric regurgitation and aspiration pneumonia. It raises pH of gastric juice and also reduces its volume and thus chances of regurgitation.
EREC 100 mg 12 F.C. TABS.SILDENAFILADWIASexual tonic64.8About Sildenafil Citrate*Phosphodiesterase-5 Enzyme Inhibitor, Anti-erectile dysfunction agent.*Mechanism of Action of Sildenafil Citrate*Sildenafil is a phosphodiesterase enzyme (PDE5) inhibitor. This enzyme is responsible for the degradation cyclic guanosine monophosphate (cGMP) produced in reaction to sexual stimulation. The more cGMP is available, the more durable the erection. Sildenafil inhibits the PDE5 enzyme, preserving cGMP levels, therefore aiding erection viability and durability *Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis and at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis. *Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the corpora cavernosa of the penis.
EZASTATIN 10/10 10tab.ATORVASTATIN -- EZETIMIBEADWIAAntihyperlipidemic.Cholesterol Absorption Inhibitors.Combined with statin32Indications for Atorvastatin -- Ezetimibe*1.Homozygous familial hypercholesterolemia *2.Combined hyperlipidaemia *Typical Dosage for Atorvastatin -- Ezetimibe*Adult: 1 tablet / day*About Ezetimibe*Cholesterol Absorption Inhibitor, 2-Azetidinone derivative, Hypolipidemic agent.*Mechanism of Action of Ezetimibe*It reduces the absorption of cholesterol from the intestine by localising at the brush border of the small intestine, where it inhibits the absorption of cholesterol from the diet. Specifically, it appears to bind to the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelium, a critical mediator of cholesterol absorption. This decreased cholesterol absorption leads to an increase in LDL-cholesterol uptake into cells, thus decreasing levels in the blood plasma.*About Atorvastatin*HMG-CoA Reductase Inhibitor, statins, Antilipemic agent.
EZASTATIN 10/40 10tab.ATORVASTATIN -- EZETIMIBEADWIAAntihyperlipidemic.Cholesterol Absorption Inhibitors.Combined with statin45Indications for Atorvastatin -- Ezetimibe*1.Homozygous familial hypercholesterolemia *2.Combined hyperlipidaemia *Typical Dosage for Atorvastatin -- Ezetimibe*Adult: 1 tablet / day*About Ezetimibe*Cholesterol Absorption Inhibitor, 2-Azetidinone derivative, Hypolipidemic agent.*Mechanism of Action of Ezetimibe*It reduces the absorption of cholesterol from the intestine by localising at the brush border of the small intestine, where it inhibits the absorption of cholesterol from the diet. Specifically, it appears to bind to the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelium, a critical mediator of cholesterol absorption. This decreased cholesterol absorption leads to an increase in LDL-cholesterol uptake into cells, thus decreasing levels in the blood plasma.*About Atorvastatin*HMG-CoA Reductase Inhibitor, statins, Antilipemic agent.
FERROJECT 12.5mg/ml amp. For I.V. inf. Or slow I.V. inj.IRONADWIAAnemia.Iron Supplement9"Description *A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia.**Indication *Used in preventing and treating iron-deficiency anemia.**Mechanism of action *Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia."
HEPATIC FORTE 30 soft gelatin Caps.OROTIC ACID -- PHOSPHOLIPIDS -- SILYMARINEADWIALiver Support Supplement21About Silymarin*A polyphenolic flavonoid, Hepatoprotective(antihepatotoxic),antioxidant.*Mechanism of Action of Silymarin*Silymarin stimulates RNA polymerase A and results in an increase in ribosomal protein synthesis and leads to the synthesis of new hepatocytes and also increase the regenerative ability of the liver. *It stabilizes the hepatic cell membrane and prevents the penetration of toxin in to the cell and also slows the absorption of harmful substances in to the liver. *Silymarin contains antioxidant flavanoid. It combines with free radicals formed from metabolic process and also from breakdown of toxic substances and neutralizes them. Because of its antioxidant action it has anti-inflammatory property and it is used in ulcerative colitis and in ulcers. *It increases the glutathione content in the liver and intestine and also increases the activity of super oxide dismutase enzymes and is helpful in detoxifying actions of liver.
INCONT L.A. 4mg 30 tab.TOLTERODINE L TARTARATEADWIAUrinary incontinence.Antispasmodics.Muscarinic Antagonists66About Tolterodine Tartarate*Anticholinergic ( antimuscarinic), Treat urinary incontinence.*Mechanism of Action of Tolterodine Tartarate*Tolterodine tartrate is a specific muscarinic receptor (M3 receptor) antagonist. It blocks muscarinic receptors which can be found on the muscle cells of the bladder wall. It prevents the action of acetyl choline on these receptors. Acetylcholine acting on these receptors causes the muscle in the bladder wall to contract, and the bladder to empty. By preventing this, Tolterodine helps the muscle in the bladder wall to relax. This reduces unstable, involuntary contractions of the bladder, and thereby increases the capacity of the bladder to hold urine. This in turn reduces the need to pass urine. *Stimulation of muscarinic receptors causes the bladder to contract and empty. Tolterodine relax the involuntary muscle in the wall of the bladder.
ITRANOX 100mg 15 Caps.ITRACONAZOLEADWIAantifungals.Triazoles54About Itraconazole*A synthetic triazole derivative, Systemic Antifungal.**Mechanism of Action of Itraconazole*Itraconazole is a fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis in fungi.**Indications for Itraconazole*1.Histoplasmosis *2.Blastomycosis *3.Aspergillosis *4.Oropharyngeal candidiasis *5.Oesopharyngeal candidiasis *6.Vaginal candidiasis *7.Sporotrichosis *8.Coccidioidomycosis *9.Paracoccidioidomycosis *10.Tinea pedis *11.Tinea corporis *12.Tinea versicolor *13.Tinea cruris *14.Chromomycosis
IVERMINE 10mg/10ml 15ml susp.IVERMECTINADWIAAnthelmintic2.75"Description *Ivermectin is a broad-spectrum anti-parasite medication. It was used against worms (except tapeworms), but, in 2012, it was approved for the topical treatment of head lice infestations in patients 6 months of age and older**Mechanism of action*Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Ivermectin also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. Ivermectin may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms."
IVERMINE 6mg 2 Caps.IVERMECTINADWIAAnthelmintic2.25"Description *Ivermectin is a broad-spectrum anti-parasite medication. It was used against worms (except tapeworms), but, in 2012, it was approved for the topical treatment of head lice infestations in patients 6 months of age and older**Mechanism of action*Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Ivermectin also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. Ivermectin may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms."
KETOPROF 100mg/2ml 5 I.M amp.KETOPROFENADWIANSAID.Propionic acid derivatives11.75About Ketoprofen*NSAID, propionic acid derivative, Analgesic,antipyretic,antiinflammatory.**Mechanism of Action of Ketoprofen*It inhibits cyclo oxygenase enzymes both COX1 and COX2.These cyclooxygenase enzyme catalyses the synthesis of prostaglandins from arachidonic acid in the tissue. These inhibition produces its analgesic, antipyretic and anti inflammatory effects. It can also stabilize the lysosomal membrane. It is a Non Steroidal Anti Inflammatory Drug. It is a propionic acid derivative.**Indications for Ketoprofen*1. Rheumatoid arthritis *2. Osteo arthritis *3. Pain due to dysmenorrhea *4. Treatment for exacerbations of musculo skeletal, periarticular and soft tissue disorders *5. Migraine *6. Gout-Acute attack
KETOPROF 200mg 14 E.R. caps.KETOPROFENADWIANSAID.Propionic acid derivatives15About Ketoprofen*NSAID, propionic acid derivative, Analgesic,antipyretic,antiinflammatory.**Mechanism of Action of Ketoprofen*It inhibits cyclo oxygenase enzymes both COX1 and COX2.These cyclooxygenase enzyme catalyses the synthesis of prostaglandins from arachidonic acid in the tissue. These inhibition produces its analgesic, antipyretic and anti inflammatory effects. It can also stabilize the lysosomal membrane. It is a Non Steroidal Anti Inflammatory Drug. It is a propionic acid derivative.**Indications for Ketoprofen*1. Rheumatoid arthritis *2. Osteo arthritis *3. Pain due to dysmenorrhea *4. Treatment for exacerbations of musculo skeletal, periarticular and soft tissue disorders *5. Migraine *6. Gout-Acute attack
LEPTROGINE 200mg 30 tab.LAMOTRIGINEADWIAAnti-epileptic.Triazine90About Lamotrigine*Phenyltriazine derivative, Anticonvulsant,Mood stabilizer.**Mechanism of Action of Lamotrigine*Lamotrigine prolongs the inactivated state of voltage sensitive neuronal sodium ion channel either by increasing the efflux or decreasing the influx of sodium ion across the cell membrane and inhibits the high frequency firing of neurons. *It blocks the voltage sensitive sodium ion channel and stabilizes the presynaptic membrane. It also prevents the release of excitatory neurotransmitters such as glutamate and aspartate receptors **Interactions for Lamotrigine*Phenytoin, carbamazepine, phenobarbitone and primidone: Enhance the metabolism of lamotrigine and may increase dose requirements. *Sodium Valproate: Reduces the metabolism of lamotrigine. *There is no evidence that lamotrigine causes clinically significant induction or inhibition of hepatic oxidative drug-metabolizing enzymes.
LEPTROGINE 25mg 30 chewable tab.LAMOTRIGINEADWIAAnti-epileptic.Triazine21About Lamotrigine*Phenyltriazine derivative, Anticonvulsant,Mood stabilizer.**Mechanism of Action of Lamotrigine*Lamotrigine prolongs the inactivated state of voltage sensitive neuronal sodium ion channel either by increasing the efflux or decreasing the influx of sodium ion across the cell membrane and inhibits the high frequency firing of neurons. *It blocks the voltage sensitive sodium ion channel and stabilizes the presynaptic membrane. It also prevents the release of excitatory neurotransmitters such as glutamate and aspartate receptors **Interactions for Lamotrigine*Phenytoin, carbamazepine, phenobarbitone and primidone: Enhance the metabolism of lamotrigine and may increase dose requirements. *Sodium Valproate: Reduces the metabolism of lamotrigine. *There is no evidence that lamotrigine causes clinically significant induction or inhibition of hepatic oxidative drug-metabolizing enzymes.
MANTINE 10mg 10f.c.tab.MEMANTINEADWIA40About Memantine*N-Methyl-D-Aspartate Receptor Antagonist, dopamine D2 agonist, Antidementia agent,In Alzheimer`s disease.*Mechanism of Action of Memantine*Memantine in an uncompetitive (low to moderate affinity to) NMDA (N-methyl-D-aspartate) receptor antagonist. It regulates the activity of glutamate which is involved in information processing, storage and retrieval. Excess glutamate plays a role in neuronal cell death and it is common to all neurodegenerative diseases. *In Alzheimer`s disease excess release of glutamate occurs. Sustained elevation of glutamate over stimulates NMDA receptors and allows too much of calcium in to nerve cells and leads to cell degeneration and cell death. Memantine prevents these actions by inhibiting the binding of glutamate at NMDA receptor.
MYOGREL 75mg 30f.c.tab.CLOPIDOGRELADWIAAntiplatlet.ADP receptor blocker120About Clopidogrel*Thienopyridine class, Platelet Aggregation Inhibitor, Antithrombic, Anti platelet agent.*Mechanism of Action of Clopidogrel*The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It alters surface receptors in platelets and inhibits ADP induced platelet-fibrinogen and platelet-platelet binding and prevents platelet aggregation. It blocks G-protein coupled P2YAC type of inhibitory purinergic receptors which mediates adenylyl cyclase inhibition by ADP. It prolongs bleeding time.**Indications for Clopidogrel*1. To reduce atherosclerotic events *2. Thrombotic disorders *3. Prevention of stroke *4. Prophylaxis of myocardial infarction *5. Peripheral vascular diseases *6. Coronary artery diseases.
MYOGREL PLUS 75/75MG 30 f.c.tab.CLOPIDOGREL -- ACETYLSALICYLIC ACIDADWIAAntiplatlet.ADP receptor blocker147About Clopidogrel*Thienopyridine class, Platelet Aggregation Inhibitor, Antithrombic, Anti platelet agent.*Mechanism of Action of Clopidogrel*The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It alters surface receptors in platelets and inhibits ADP induced platelet-fibrinogen and platelet-platelet binding and prevents platelet aggregation. It blocks G-protein coupled P2YAC type of inhibitory purinergic receptors which mediates adenylyl cyclase inhibition by ADP. It prolongs bleeding time.**Indications for Clopidogrel*1. To reduce atherosclerotic events *2. Thrombotic disorders *3. Prevention of stroke *4. Prophylaxis of myocardial infarction *5. Peripheral vascular diseases *6. Coronary artery diseases.
NOPECIA 1mg 30 Caps.FINASTERIDEADWIA36About Finasteride*5 Alpha-Reductase Inhibitor, Synthetic anti-androgen.**Mechanism of Action of Finasteride*This synthetic 4-azasteroid derivative competitively inhibits steroid 5alpha reductase, which is an enzyme responsible for active androgen dehydrotestosterone (this enzyme influences the development of prostate gland, so decreasing level of this hormone relieve the symptoms associated with benign prostatic hyperplasia)from testosterone.**Indications for Finasteride*1. Benign prostatic hyperplasia *2. 1st stage of prostate cancer *3. Hirsuitism *4. Acne *5. Adjuvant therapy of radical prostectomy *6. Androgenic baldness
ORASTRINE 200ml mouthwashEUCALYPTOL -- MENTHOL -- METHYL SALICYLATE -- THYMOLADWIA12"Description *Eucalyptol is a natural organic compound which is a colorless liquid. It is a cyclic ether and a monoterpenoid. Eucalyptol is an ingredient in many brands of mouthwash and cough suppressant. It controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition. Eucalyptol is an effective treatment for nonpurulent rhinosinusitis. Eucalyptol reduces inflammation and pain when applied topically. It kills leukaemia cells in vitro."
OSMORAN 300mg 14 f.c.tabRANITIDINEADWIAPeptic Ulcer.Anti-Histamine.H2 Antagonist28.8About Ranitidine*A histamine H2-receptor antagonist, Furan derivative, Anti-secretory G.I agent,Anti ulcer.*Mechanism of Action of Ranitidine*Ranitidine is a H2 (Histamine) receptor antagonist. Histamine is the most potent stimulus of acid secretion and acts as the common mediator. H2 receptor is a G-protein coupled receptor. It induces adenylate cyclase which converts ATP to cyclic AMP. This cyclic AMP acts on proton pump and exchange extracellular potassium ion for intracellular hydrogen ion across the parietal cell membrane. Ranitidine reversibly competes with Histamine for binding to H2 receptors on the parietal cells and predominantly inhibits basal acid secretion. *Anaesthetic adjuncts: It is used in patients undergoing prolonged operations, caesarian section,obese patients those are at increased risk of gastric regurgitation and aspiration pneumonia. It raises pH of gastric juice and also reduces its volume and thus chances of regurgitation.
OSTEONATE 10mg 10 tab.ALENDRONATE SODIUMADWIAOsteoporosis.Bisphosphonates33.6About Alendronate Sodium*Bisphosphonate Derivative, Bone resorption inhibitor. **Mechanism of Action of Alendronate Sodium*It preferentially localized to the sites of action and inhibits prenylation of GTP-binding proteins involved in cytoskeletal organization, membrane ruffling and vesicle movement. This results by osteoclasts inactivation, impaired vesicle fusion and enhanced apoptosis (bone resorption inhibition).*Indications for Alendronate Sodium*1. Osteoporosis *2. Paget`s disease **Interactions for Alendronate Sodium*Asprin: Risks of upper GI adverse effects increased. *Calcium supplements antacids: Interfere with absorption of alendronate.
OSTEONATE 70mg 4tab.ALENDRONIC ACIDADWIA40"Indication *For the treatment and prevention of osteoporosis in women and Paget s disease of bone in both men and women.*Mechanism of action The action of Alendronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Alendronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average,"
OSTEONATE PLUS 4 tab.ALENDRONIC ACID -- VITAMIN D3ADWIA46**Therapeutic indications:*It is indicated for the treatment of postmenopausal osteoporosis in women at risk of vitamin D insufficiency. It reduces the risk of vertebral and hip fractures.****Posology and method of administration*The recommended dose is one tablet once weekly.*Patients should be instructed that if they miss a dose of OSTEONATE PLUS they should take one tablet on the morning after they remember. They should not take two tablets on the same day but should return to taking one tablet once a week, as originally scheduled on their chosen day.**Due to the nature of the disease process in osteoporosis, OSTEONATE PLUS is intended for long-term use.**Patients should receive supplemental calcium if intake from diet is inadequate. Additional supplementation with vitamin D should be considered on an individual basis taking into account any vitamin D intake from vitamins and dietary supplements.
PENTOXAL 100mg/5ml amp.PENTOXIFYLLINEADWIAAnti-Ischemic5About Pentoxifylline*A xanthine derivative, Phosphodiesterase inhibitor, Blood viscosity reducing agent.*Mechanism of Action of Pentoxifylline*The drug exerts its pharmacological action by improving rheological (flow) properties of blood. It improves blood flow to ischaemic areas by increasing capillary blood flow by improving erythrocyte flexibility and reducing blood viscosity. It inhibits phosphodiesterase enzyme.*Indications for Pentoxifylline*1.Intermittent claudication *2.Occlusive arterial diseases of limbs *3.Cerebrovascular insufficiency *4.Circulatory disorder due to arteriosclerosis *5.Trophic disorders *6.Acute non haemorrhagic stroke *7.Other chronic occlusive vascular disorders *Interactions for Pentoxifylline*Warfarin: Bleeding and prolonged prothrombin time in patients receiving pentoxifylline with or without anticoagulants or platelet aggregation inhibitors. PT(Prothrombin Time) should be monitored in patients on warfarin.
PEPTOLANZ 30mg 21 Caps.LANZOPRAZOLADWIAPeptic Ulcer.proton pump inhibitor54"Description *Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid. It is manufactured by TAP Pharmaceutical Products**Mechanism of action *Lansoprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but rather suppress gastric acid secretion by specific inhibition of the (H -- ,K -- )-ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the parietal cell, Lansoprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus."
PREGESICAN 75 mg 20 hard gelatin Caps.PREGABALINADWIAAnti-epileptic.GABA analogs46About Pregabalin*A GABA agonist, Anticonvulsant.*Mechanism of Action of Pregabalin*Pregabalin is a GABA neurotransmitter analog. It produces its action by modulating calcium channels and also reduces the release of neurotransmitters such as Glutamate, Norepinephrine, Serotonin, Dopamine and Substance P.*Indications for Pregabalin*1.Epilepsy *2.Generalised anxiety disorder *3.Neuropathic pain *Typical Dosage for Pregabalin*150- 300mg / day in 2 divided doses
PROFENAZONE 20 Caps.CHLORZOXAZONE -- IBUPROFENADWIA12"(Indications) : *This medication is a muscle relaxant, prescribed for muscle spasm and the resulting pain or discomfort. It is used in combination with physical therapy, analgesics (such as aspirin or acetaminophen), and rest. *About Chlorzoxazone*A benzoxazolone derivative, Centrally acting Muscle relaxant and mild sedative.*Mechanism of Action of Chlorzoxazone*This muscle relaxant works by blocking nerve impulses (or pain sensations) that are sent to your brain. It inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. It may also reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium influx. ***"
PROSTRIDE 5mg 30 Caps.FINASTERIDEADWIA109.25About Finasteride*5 Alpha-Reductase Inhibitor, Synthetic anti-androgen.**Mechanism of Action of Finasteride*This synthetic 4-azasteroid derivative competitively inhibits steroid 5alpha reductase, which is an enzyme responsible for active androgen dehydrotestosterone (this enzyme influences the development of prostate gland, so decreasing level of this hormone relieve the symptoms associated with benign prostatic hyperplasia)from testosterone.**Indications for Finasteride*1. Benign prostatic hyperplasia *2. 1st stage of prostate cancer *3. Hirsuitism *4. Acne *5. Adjuvant therapy of radical prostectomy *6. Androgenic baldness
RANDIL 20mg 30 tab.NICORANDILADWIAAnti-Ischemic42About Nicorandil*A potassium channel opener,a vasodilator, Antianginal.*Mechanism of Action of Nicorandil*The drug exerts antianginal action by activating ATP sensitive potassium channels which leads to hyperpolarizing vascular smooth muscle and ultimate vasodilatation. It also acts as a nitric oxide donor relaxes blood vessels by increasing cyclic GMP and hence arterial dilatation is coupled with venodilatation. Dilatations of both epicardial conducting vessels and deeper resistance vessels have occurred and coronary flow is increased. Improves exercise tolerance and reduce frequency of angina. Mitochondrial K -- ATP channel opening by Nicorandil also exerts myocardial protection by a process of ischaemic preconditioning which reduce myocardial stunning, arrhythmias and infarct size when a coronary artery is suddenly blocked. Myocardial recovery from ischaemic damage after myocardial infarction as measured by left ventricular wall motion is improved by Nicorandil.
RIBAZOLE 400mg 30 Caps.RIBAVIRINADWIAAnti-Viral.Nucleoside66About Ribavirin*A nucleoside antimetabolite, Triazole derivative, Antiviral.*Mechanism of Action of Ribavirin*Ribavirin is a nucleoside analogue and it is phosphorylated by adenosine kinase enzyme in the host cell to form Ribavirin monophosphate.This will inhibits Inosine monophosphate (IMP) formation and also cause degradation of guanosine triphosphate (GTP) .All these results in inhibition of protein synthesis and suppression of elongation of viral mRNA*Indications for Ribavirin*1. Respiratory syncytial virus (RSV) infection *2. Influenza A & B virus infection *3. Herpes simplex virus *4. Hepatitis B virus *5. Lassa fever *6. Haemorrhagic fever *7. Measles *8. Para influenza virus infection in children
RIGHT-ACE 10 mg 30 tab.RAMIPRILADWIAAnti-hypertensive.ACE66About Ramipril*Angiotensin - converting enzyme inhibitor, Antihypertensive.*Mechanism of Action of Ramipril*It is a prodrug and converted in to active Ramiprilat- which is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.
RIGHT-ACE 5mg 30 tab.RAMIPRILADWIAAnti-hypertensive.ACE51About Ramipril*Angiotensin - converting enzyme inhibitor, Antihypertensive.*Mechanism of Action of Ramipril*It is a prodrug and converted in to active Ramiprilat- which is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.
RIGHT-ACE COMP 5/25mg 10 tab.HYDROCHLOROTHIAZIDE -- RAMIPRILADWIAAnti-hypertensive.Combined ACE with diuretic19.2"This combination product contains two active ingredients: ramipril and hydrochlorothiazide. Ramipril belongs to the class of medications called ACE inhibitors. It works by relaxing blood vessels and by making the heart pump more efficiently. Hydrochlorothiazide belongs to the class of medications known as diuretics or ""water pills"" and helps control blood pressure by getting rid of excess salt and water.**Ramipril - hydrochlorothiazide is used to treat high blood pressure. This combination medication is prescribed when your doctor feels it is appropriate for you to be taking both medications and you have taken ramipril and hydrochlorothiazide as separate medications without any problems. It may take 2 to 4 weeks to see the full effects of this medication."
RISIDRONE 1mg 10f.c.tab.RISPERIDONEADWIApsychiatric.Antipsychotics10About Risperidone*Second-Generation Antipsychotic, benzisoxazole derivative, Antimanic, Atypical Antipsychotic.*Mechanism of Action of Risperidone*Risperidone exerts its antipsychotic activity by blocking Dopamine and Serotonin (5HT2) receptors. The drug has antagonistic action on alpha adrenergic and histaminergic receptors. These produce an increase in neurotransmitters concentration and thereby antipsychotic action.*Indications for Risperidone*Psychoses*Interactions for Risperidone*Levodopa : Efficacy of levodopa and dopamine agonists reduced. *Carbamazepine : Chronic administration of carbamazepine may decrease it`s efficacy. *Clozapine : Chronic administration of clozapine may enhance it`s efficacy.
RISIDRONE 3mg 10f.c.tab.RISPERIDONEADWIApsychiatric.Antipsychotics21About Risperidone*Second-Generation Antipsychotic, benzisoxazole derivative, Antimanic, Atypical Antipsychotic.*Mechanism of Action of Risperidone*Risperidone exerts its antipsychotic activity by blocking Dopamine and Serotonin (5HT2) receptors. The drug has antagonistic action on alpha adrenergic and histaminergic receptors. These produce an increase in neurotransmitters concentration and thereby antipsychotic action.*Indications for Risperidone*Psychoses*Interactions for Risperidone*Levodopa : Efficacy of levodopa and dopamine agonists reduced. *Carbamazepine : Chronic administration of carbamazepine may decrease it`s efficacy. *Clozapine : Chronic administration of clozapine may enhance it`s efficacy.
ROSTATINE 20mg 30 F.C.tab.ATORVASTATINADWIAAntihyperlipidemic.Statins72"Description : * is a member of the drug class known as statins.**dose:*Adult PO- Initial- The recommended dose is 10 mg daily. Maximum: 80 mg/day.**Indication :*May be used as primary prevention in individuals with multiple risk factors for coronary heart disease (CHD) and as secondary prevention in individuals with CHD to reduce the risk of myocardial infarction (MI), stroke, angina, and revascularization procedures. May be used to reduce the risk of cardiovascular events in patients with acute coronary syndrome (ACS). May be used in the treatment of primary hypercholesterolemia and mixed dyslipidemia, homozygous familial hypercholesterolemia, primary dysbetalipoproteinemia, and/or hypertriglyeridemia as an adjunct to dietary therapy to decrease serum total and low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), and triglyceride concentrations, while increasing high-density lipoprotein cholesterol (HDL-C) levels."
SESERINE 50mg 30 tab.SERTRALINEADWIApsychiatric.Antidepressants60About Sertraline*Selective Serotonin Reuptake Inhibitor (SSRI), Antidepressant, Antidepressant*Mechanism of Action of Sertraline*Sertraline blocks the re-uptake of neurotransmitter Serotonin from the synapse in to the presynaptic nerve terminal in the CNS. This will prolong the action of Serotonin (5HT) and it is useful in the treatment of depression.*Side Effects of Sertraline*1. Insomnia *2. Nausea *3. Diarrhoea *4. Headache *5. Fatigue *6. Dizziness *7. Tremor *8. Somnolence *9. Dry mouth *10. Anorexia *11. Impotence *12. Increased sweating *13. Constipation *14. Dyspepsia *15. Agitation *16. Malaise *17. Abdominal pain
SPASMOFREE 10mg/5ml 120ml syrupTIEMONIUM METHYLSULPHATEADWIA9Tiemonium Methylsulfate - Treatment of acute, intense or refractory painful syndromes with a spasmodic component. The use of noramidopyrine is only justified when its activity confers a real advantage over other analgesics. Indications: smooth muscle spasm
SPASMOFREE 50mg 20 F.C. TABS.TIEMONIUM METHYLSULPHATEADWIA9.78Tiemonium Methylsulfate - Treatment of acute, intense or refractory painful syndromes with a spasmodic component. The use of noramidopyrine is only justified when its activity confers a real advantage over other analgesics. Indications: smooth muscle spasm
SPASMOFREE 5mg/2ml I.V./I.M. 3 amp.TIEMONIUM METHYLSULPHATEADWIA15.75Tiemonium Methylsulfate - Treatment of acute, intense or refractory painful syndromes with a spasmodic component. The use of noramidopyrine is only justified when its activity confers a real advantage over other analgesics. Indications: smooth muscle spasm
SPECZIL 250MG/5ML 60ML SUSP.CEFPROZILADWIAAntibiotic.cephalosporin.Second-generation21About Cefprozil*Second Generation Cephalosporin antibiotic, Oral antibiotic.**Mechanism of Action of Cefprozil*Cefprozil is a short acting 2nd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefprozil inhibits transpeptidase & thus prevents cross linking of bacterial cell wall.**Indications for Cefprozil*1.Pharyngitis *2.Sinusitis *3.Pneumonia *4.Acute Bronchitis *5.Skin infection *6.Tonsillitis *7.Otitis media
STATUKAST 10 mg 10 SCORED F.C. TABS.MONTELUKASTADWIAAsthma.Anti-inflammatory.leukotriene antagonist22.8About Montelukast*Leukotriene(CysLT1) Receptor Antagonist, Antiinflammatory,antiasthma.**Mechanism of Action of Montelukast*Montelukast is competitively and selectively antagonizes CysLT1 receptor (leukotrienes receptor) mediated Bronchoconstriction.Montelukast inhibits physiologic actions of LTD 4 at the CysLT1 receptor without any agonist activity. **Indications for Montelukast*Asthma.*Interactions for Montelukast*Barbiturates & Primidone: Plasma concentration of montelukast is reduced by phenobarbital.
STATUKAST 4mg oral granules 10 sachetsMONTELUKASTADWIAAsthma.Anti-inflammatory.leukotriene antagonist33About Montelukast*Leukotriene(CysLT1) Receptor Antagonist, Antiinflammatory,antiasthma.**Mechanism of Action of Montelukast*Montelukast is competitively and selectively antagonizes CysLT1 receptor (leukotrienes receptor) mediated Bronchoconstriction.Montelukast inhibits physiologic actions of LTD 4 at the CysLT1 receptor without any agonist activity. **Indications for Montelukast*Asthma.*Interactions for Montelukast*Barbiturates & Primidone: Plasma concentration of montelukast is reduced by phenobarbital.
TALOPRAM 40mg 10f.c.tab.CITALOPRAMADWIApsychiatric.Antidepressants36About Citalopram*Selective Serotonin Reuptake Inhibitor (SSRIs), Antidepressant.**Mechanism of Action of Citalopram*Citalopram blocks the re-uptake of neurotransmitter Serotonin from the synapse to the presynaptic nerve terminal in the CNS. This potentiates the action of Serotonin (5HT) and it is useful in the treatment of depression. **Indications for Citalopram*Depression.**Contra-indications of Citalopram*1.Hypersensitivity to Citalopram, *2.Patient on MAOI (Monoamine oxidase inhibitor) therapy.*Special Precautions while taking Citalopram
TIBOLONE 2.5mg 30 tabTIBOLONEADWIA60About Tibolone*A synthetic steroid hormone,Selective tissue estrogenic activity regulator, Female sexual dysfunction drug. *Mechanism of Action of Tibolone*The drug metabolized in a tissue selective manner in to three metabolites which have estrogenic, progestogenic and weak androgenic properties. It restores plasma endorphin level in post menopausal women and stabilizes the hypothalamic pituitary systems. It increases bone mineral density and raises gonadotropin levels. It decreases vasomotor symptoms with out stimulating endometrium. It improves urogenital atrophy, psychological symptoms, libido and osteoporosis.*Indications for Tibolone*1.Menopausal vasomotor symptoms due to estrogen deficiency, *2.Osteoporosis. *Interactions for Tibolone*Antibacterials: Rifampicin: Accelerates metabolism (reduced plasma concentration). *Antiepileptics: Carbamazapine, phenobarbitone, phenytoin, primidone: Accelerate metabolism.
URIPAN 0.1% syrup 120 MLOXYBUTYNINADWIAUrinary incontinence.Antispasmodics.Muscarinic Antagonists14.25About Oxybutynin*Antimuscarinic agent, Urinary Antispasmodic Agent.**Mechanism of Action of Oxybutynin*This drug decreases muscle spasms of the bladder by competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. It also has direct spasmolytic effects on bladder smooth muscle as a calcium antagonist and local anesthetic action at high concentrations.*Indications for Oxybutynin*1. Urinary incontinence *2. Urgency and frequency in the unstable bladder *3. Nocturnal enuresis
URIPAN 5mg 30 tab.OXYBUTYNINADWIAUrinary incontinence.Antispasmodics.Muscarinic Antagonists29.25About Oxybutynin*Antimuscarinic agent, Urinary Antispasmodic Agent.**Mechanism of Action of Oxybutynin*This drug decreases muscle spasms of the bladder by competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. It also has direct spasmolytic effects on bladder smooth muscle as a calcium antagonist and local anesthetic action at high concentrations.*Indications for Oxybutynin*1. Urinary incontinence *2. Urgency and frequency in the unstable bladder *3. Nocturnal enuresis
URIPAN X.R. 10 MG 30 tab.OXYBUTYNINADWIAUrinary incontinence.Antispasmodics.Muscarinic Antagonists49.5About Oxybutynin*Antimuscarinic agent, Urinary Antispasmodic Agent.**Mechanism of Action of Oxybutynin*This drug decreases muscle spasms of the bladder by competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. It also has direct spasmolytic effects on bladder smooth muscle as a calcium antagonist and local anesthetic action at high concentrations.*Indications for Oxybutynin*1. Urinary incontinence *2. Urgency and frequency in the unstable bladder *3. Nocturnal enuresis
VAGIPROST 25 mcg 4 Vag.tabs.MISOPROSTOLADWIA12About Misoprostol*A synthetic prostaglandin E1 (PGE1) analogue, Anti ulcer(antisecretory and protective),Abortifacient.*Mechanism of Action of Misoprostol*Misoprostol is a synthetic Prostaglandin E1 analog. It binds to the EP3 receptor on the basolateral membrane of the parietal cells and stimulates the inhibitory G protein (Gi) receptors. This will leads to decrease in intracellular cyclic AMP level and inhibits proton pump (H -- K -- ATPase) which exchange the extracellular K -- for intracellular H -- ion. By inhibiting the proton pump Misoprostol decreases gastric acid secretion. Misoprostol also binds to the EP3 receptor on the superficial epithelial cells of the lumen and stimulates the mucin and bicarbonate secretion and decreases nocturnal, basal and stimulated gastric acid secretion.
VEGAPANTIN 5gm/100ml syp. 120 MLGABAPENTINADWIAAnti-epileptic.GABA analogs24About Gabapentin*A GABA analogue, Anticonvulsant, Mood stabilizer.**Mechanism of Action of Gabapentin*Gabapentin is a GABA derivative and it bounds to lipophilic molecule. The mechanism of action of Gabapentin is not exactly known. It crosses blood brain barrier and enhances release of GABA.**Indications for Gabapentin*1.Antiepileptic(Treatment of partial seizure) *2.Treatment of neuropathic pain **Typical Dosage for Gabapentin*Adult: Initial dose: 300 mg / day increase the dose by 300 mg/day for next 2 days (up to 900 mg / day in 3 divided doses). Thereafter increase the dose until sufficient therapeutic response is obtained. *Maintenance dose: 900-1800mg /day in 3 divided doses *Maximum dose: 3.6 g /day *Children above 12 years: 10mg / kg / day in 3 divided doses, then gradually increase the dose until sufficient therapeutic response is obtained.
VEGAPANTIN 600mg 10 F.C.tab.GABAPENTINADWIAAnti-epileptic.GABA analogs30About Gabapentin*A GABA analogue, Anticonvulsant, Mood stabilizer.**Mechanism of Action of Gabapentin*Gabapentin is a GABA derivative and it bounds to lipophilic molecule. The mechanism of action of Gabapentin is not exactly known. It crosses blood brain barrier and enhances release of GABA.**Indications for Gabapentin*1.Antiepileptic(Treatment of partial seizure) *2.Treatment of neuropathic pain **Typical Dosage for Gabapentin*Adult: Initial dose: 300 mg / day increase the dose by 300 mg/day for next 2 days (up to 900 mg / day in 3 divided doses). Thereafter increase the dose until sufficient therapeutic response is obtained. *Maintenance dose: 900-1800mg /day in 3 divided doses *Maximum dose: 3.6 g /day *Children above 12 years: 10mg / kg / day in 3 divided doses, then gradually increase the dose until sufficient therapeutic response is obtained.
ZETAMIBE 10 mg 10 tab.EZETIMIBEADWIA34.8About Ezetimibe*Cholesterol Absorption Inhibitor, 2-Azetidinone derivative, Hypolipidemic agent.**Mechanism of Action of Ezetimibe*It reduces the absorption of cholesterol from the intestine by localising at the brush border of the small intestine, where it inhibits the absorption of cholesterol from the diet. Specifically, it appears to bind to the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelium, a critical mediator of cholesterol absorption. This decreased cholesterol absorption leads to an increase in LDL-cholesterol uptake into cells, thus decreasing levels in the blood plasma.**Indications for Ezetimibe*1. Adjunct to dietary measures and statin in primary and homozygous familial hypercholesterolaemia *2. Adjunct to dietary measures in homozygous familial sitosterolaemia
ZYMADONE 10mg oral 10Dis.tab.DONEPEZILADWIA60About Donepezil*Central Acetylcholinesterase inhibitor, Antidementia agent in Alzheimer`s disease.**Mechanism of Action of Donepezil*Alzheimer`s disease may result from a deficiency in neurotransmitters used by nerves in the brain to communicate with one another. Donepezil exerts its therapeutic effect by enhancing its cholinergic function. It increases the concentration of Acetylcholine through reversible inhibition of acetyl cholinesterase enzyme which is involved in the hydrolysis of Acetylcholine. It leads to increased concentration of Acetylcholine.This increased Acetylcholine concentrations are believed to be responsible for the improvement seen during treatment with donepezil.**Interactions for Donepezil*Antiarrhythmics: Procainamide, quinidine and probably propafenone antagonise effect of neostigmine & pyridostigmine. *Antibacterials : Aminoglycosides, clindamycin & colistin antagonise effect of neostigmine & pyridostigmine. *Antimuscarinics: Antagonism of effect. *

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